Mal J Nutr 23(3): 461-471, 2017

Antidiabetic and Immunomodulatory Potential of Purple Soymilk Enriched with Crude Palm Oil Microcapsule in Type- 2 Diabetes Mellitus Respondents
Reno Fitri Hasrini12, Fransiska Rungkat Zakaria1*, Dede Robiatul Adawiyah1& Irma Herawati Suparto3,4

1 Department of Food Science and Technology, Faculty of Agricultural Engineering, Bogor Agricultural University, Kampus IPB Darmaga, Bogor-16680, Indonesia
2 Center for Agro-Based Industry, Ministry of Industry Affairs, Republic of Indonesia, Ir. H. Juanda 11, Bogor-16122, Indonesia
3 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Darmaga, Bogor-16680, Indonesia
4 Primate Research Center Bogor Agricultural University, Kampus IPB Cilibende, Bogor-16151, Indonesia


ABSTRACT

Introduction: Purple soymilk produced from black soybean has been reported to reduce fasting blood glucose (FBG) and HbA1c of type 2 diabetes mellitus (T2DM) patients. Crude palm oil (CPO) is known to have immunomodulatory activity. This study aimed to investigate the antidiabetic and immunomodulatory potential of purple soymilk enriched with CPO microcapsule (PSPOM) in T2DM respondents. Methods: A total of 25 T2DM patients from Katili clinic and Bogor Agricultural University, Indonesia were recruited by purposive cluster sampling, and divided into control and test groups. The test group consumed PSPOM, made up of 240 mL of purple soymilk with 0.4 g CPO microcapsule, containing 295.24 µg carotenoid/g capsule daily for 4 weeks. Blood sample of 2 mL was collected from each subject before and after the intervention. Dietary intakes were assessed using the 24-h food recall method. Results: When compared between the start and end of the intervention, the test group showed significant mean decreases in fasting blood glucose from 177.20 ± 93.55 to 154.87 ± 71.13 mg/dL, and in HbA1c from 0.29 ± 0.07 to 0.26 ± 0.06 OD450. The test group also showed a mean increase of IL-6 level from 0.23 ± 0.04 to 0.25 ± 0.06 OD450 , and significant increases in the level of insulin from 0.18 ± 0.05 to 0.21 ± 0.07 OD450 over the same duration. Results also showed increases of CD4+ from 563.13 ± 194.62 to 679.95 ± 278.86 cell/µL blood, and CD8+ T cells from 317.91 ± 105.40 to 343.74 ± 162.27 86 cell/µL blood during the intervention period. Conclusion: Consumption of PSPOM in this study showed potential antidiabetic and immunomodulatory activities in T2DM respondents. Further studies should be undertaken to confirm these results.

Keywords: Antidiabetic, crude palm oil, immune-modulatory activity, microcapsules, purple soymilk

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